Elinzanetant (Lynkuet)
A dual NK1/NK3 blocker for hot flashes and sleep.
VIDEO LESSON
How it's taken
• Once daily at bedtime
Side effects at a glance
• Headache and fatigue
• Sleepiness and dizziness: avoid driving if affected
Monitoring
Your clinician will review interactions, particularly with medicines that strongly affect the liver enzyme CYP3A4, and follow the label's lab guidance.
Good to know
Trials measured improvements in sleep disturbance as well as hot flashes. OASIS-4 studied women taking endocrine therapy for breast cancer.
AT A GLANCE
Class
Non-hormonal
Brand names
Lynkuet
Status
FDA-approved
Reviewed by
Farhan Tahir, MD
Is this medicine right for you?
Prescription medicines need individual medical advice. Dr. Tahir’s team offers consults through Youthful Medicine.
MECHANISM
How it works
Blocks both neurokinin-1 and neurokinin-3 receptors in the hypothalamus, calming the overactive temperature-control signal behind hot flashes. Taken as a 120 mg capsule dose once daily at bedtime.
THE EVIDENCE
What the research actually shows.
EVIDENCE SUMMARY
Approved by the FDA on October 24, 2025 for moderate to severe hot flashes caused by menopause. In the OASIS 1 and 2 trials it reduced hot-flash frequency and severity versus placebo and improved sleep disturbance, and the 52-week OASIS 3 trial showed the benefit was sustained.
KEY TRIALS
OASIS 1 · OASIS 2 · OASIS 3
TYPICAL RESULT
Fewer, milder hot flashes plus better sleep scores
SAFETY
Risks, side effects and who should avoid it
The most common side effects are headache, fatigue, dizziness and sleepiness. It can depress the central nervous system, so avoid driving or alcohol until you know how it affects you. Not for use in pregnancy.
This summary is not a complete list of risks. Read the official prescribing information and discuss your own history with your clinician.
KEY REFERENCE
LYNKUET (elinzanetant) capsules. U.S. prescribing information, October 2025.
Educational content only, reviewed by Farhan Tahir, MD. Not individual medical advice. Medicines named here require a prescription and medical supervision.